From Twitter:
Do (.) “Do“ is a statement; it means something like “go ahead.”
……・you (?) “Do you?” is a tag question, meaning “do you (+ an implied basic verb)?”
……….・know (?) “Do you know?” asks whether the listener(s) are aware.
………………..・what (?) “Do you know what?” is an interjection and audience.
……………………….・time (?) “Do you know what time?” asks an event time.
……………………………….・it is? “Do you know what time it is?” (asks the given time or the time of an event.)
……………………………………….・we should be there? “Do you know what time we should be there?” asks about an expected or desirable arrival time.
………………………………………・it starts? “Do you know what time it starts?” asks about the time something begins, like a movie-start-time.
………………………………………・where (?) “Do you know where?” asks a location.
…………………………………………………..・it is (?) “Do you know where it is?” asks about the placement or location of a third-person specific object.
…………………………………………………..・we are? “Do you know where we are? asks whether the listener(s) knows the location of the the speaker, him- or her-self and the listener(s).
…………………………………………………..・should be ? “Do you know where we should be?” asks what location the speaker and listener(s) and (an)other(s) must be in or are expected at.
………………..・me? “Do you know me?” asks whether the listener(s) knows the speaker as a person or his or her identity.
………………..・the Ims?* “Do you know the Ims?” asks whether the listener(s) knows the Im family. *a family name
………………..・it? “Do you know it?” asks whether the listener(s) knows something that’s been referenced.
………………..・how (?) “Do you know how?” asks whether the listener(s) is aware of a method.
………………………….・to go? “Do you know how to go?” asks whether the listener(s) are aware of a way or path or route.
………………………………・do it? “Do you know how to do it? asks whether the listener(s) are aware of a specific method already referred to.
Tomomi: I ① the Kita Ku City Hall Children’s Center ② infected with 
